Adult Human Mesenchymal Stem Cells Delivered via Intra-Articular Injection to the Knee Following Partial Medial Meniscectomy
نویسندگان
چکیده
Investigation performed at the University of Southern California Orthopaedic Surgery Associates, Keck School of Medicine, Los Angeles, California, Unlimited Research, San Antonio, Texas, Triangle Orthopaedic Associates, Durham, North Carolina, Orthopaedic Center of Vero Beach, Vero Beach, Florida, OrthoIndy, Indianapolis, Indiana, TRIA Orthopaedic Center, Bloomington Minnesota, and Greater Chesapeake Orthopaedic Associates, Baltimore, Maryland
منابع مشابه
Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study.
BACKGROUND There are limited treatment options for tissue restoration and the prevention of degenerative changes in the knee. Stem cells have been a focus of intense preclinical research into tissue regeneration but limited clinical investigation. In a randomized, double-blind, controlled study, the safety of the intra-articular injection of human mesenchymal stem cells into the knee, the abili...
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Knee osteoarthritis (OA) after partial or total meniscectomy is a prevalent issue that patients must face. Various methods of replacing meniscal tissue have been studied to avoid this progression, including meniscal allograft transplantation, meniscal scaffolds, and synthetic meniscus replacement. Studies have shown that meniscal scaffolds may improve symptoms but have not been shown to prevent...
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Background & Aims: One of cell- based technical issues associated with cartilage repair assay is delivering cells to the site of the parts where damage is created. Mesenchymal stem cells (MSCs) with their chondrogenic potential are ideal candidates for cartilage regeneration. High expression of cartilage hypertrophy markers by MSCs would result in apoptosis and ossification. This investigation ...
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Treatment options for meniscus pathology, or more specifically meniscal deficiency, are limited, with the primary focus being on meniscal preservation. Ever since 1948, when Fairbank introduced the concept of the post-meniscectomy knee, we have struggled to develop an improved treatment strategy for knees following a partial or complete meniscectomy. As the rate of meniscal injuries continues t...
متن کاملStem cell therapy in a caprine model of osteoarthritis.
OBJECTIVE To explore the role that implanted mesenchymal stem cells may play in tissue repair or regeneration of the injured joint, by delivery of an autologous preparation of stem cells to caprine knee joints following induction of osteoarthritis (OA). METHODS Adult stem cells were isolated from caprine bone marrow, expanded in culture, and transduced to express green fluorescent protein. OA...
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